Our research focuses on applying systems analysis approaches and engineering tools to identify novel clinical therapeutic targets for complex diseases. It is challenging to develop new treatments for these diseases, such as Alzheimer’s disease (AD) and inflammatory bowel disease (IBD), because they do not have a single genetic cause and they simultaneously present broad physiologic changes. By combining novel engineered in vitro platforms, mouse models, and multivariate computational systems analysis, we will be able to 1) capture a holistic systems-level understanding of complex diseases, and 2) isolate specific mechanisms driving disease. The ultimate goal of our laboratory is to use these tools to identify new mechanisms driving disease onset and progression that will translate to effective therapeutic strategies.
Updates: Getting Started at Georgia Tech!
Dr. Wood joined Georgia Tech as an Assistant Professor in August 2015. Prior to his current appointment, he was a postodctoral fellow at the Best Israel Deaconess Medical Center, Massachusetts General Hospital and Harvard Medical School. There he used systems biology to elucidate novel signaling mechanisms in Alzheimer’s disease and intestinal inflammation. Dr. Wood received his Ph.D. in mechanical engineering at the Massachusetts Institute of Technology, where he developed and used a microfluidic platform to identify dominant mechanisms governing vascular geometry during early vascular growth.
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