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In the Pardue Lab, we are focused on developing life-changing treatments for people with vision loss. Steps to successful treatment require understanding mechanism(s) of the disease and characterizing temporal changes to identify therapeutic windows, with the ultimate goal of rehabilitation of visual function. We use behavioral, electrophysiological, morphological, molecular, and imaging approaches to evaluate changes in retinal function and structure. Our research is guided by applying knowledge of retinal circuits and visual processing, often leading to studies of cognition and the interaction of retinal and visual circuits during health and disease. Our studies start in animal models and move to human trials when possible. We have three main areas of focus:
 
Principal Investigator:
Machelle Pardue, PhD
 
Postdoctoral Fellows:
Rachael Allen, PhD
Andrew Feola, PhD
Graduate Students:
Dillon Brown
Bailey Hannon
Erica Landis
Lab Technicians:
Monica Coulter, PhD
Lukas Mees
Cara Motz
Victoria Yang
 
 
 
Kyle Chesler
Undergraduate Students:
Ryan Dunn
Jenny Fu
 
Ryan Strickland
 

PUBLICATIONS


Hanif, AM, Kim, MK, Thomas, JG, Ciavatta, VT, Chrenek, M, Hetling, JR, Pardue, MT (2016) Whole-eye electrical stimulation therapy preserves visual function and structure in P23H-1 rats. Exp. Eye Res. 149:75-83
Chrenek, MA, Sellers, JT, Lawson, EC, Cunha, PP, Johnson, JL, Girardot, PE, Kendall, C, Han, MK, Hanif, A, Ciavatta, VT, Gogniat, MA, Nickerson, JM, Pardue, MT, Boatright, JH (2016) Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns. Adv. Exp. Med. Biol. 854:443-8
Lawson, EC, Bhatia, SK, Han, MK, Aung, MH, Ciavatta, V, Boatright, JH, Pardue, MT (2016) Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice. Adv. Exp. Med. Biol. 854:431-6
Deming, JD, Pak, JS, Shin, JA, Brown, BM, Kim, MK, Aung, MH, Lee, EJ, Pardue, MT, Craft, CM (2015) Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina. Invest. Ophthalmol. Vis. Sci. 56(13):7618-28
Hanif, AM, Lawson, EC, Prunty, M, Gogniat, M, Aung, MH, Chakraborty, R, Boatright, JH, Pardue, MT (2015) Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model. Invest. Ophthalmol. Vis. Sci. 56(11):6839-46
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