Proteins usually do not act alone. From macromolecular machinery to antibody/antigen complexes, protein-protein interactions play an essential role in a living cell. How do proteins interact with each other? High resolution structures of protein-protein complexes provide valuable insights into the mechanisms of protein-protein interactions. Structural comparison of protein-protein interfaces further facilitates studies of protein-protein interaction modes and helps to infer relationship between proteins. iAlign is a program designed for the comparison of the structures of protein-protein interfaces.
Details of the program can be found in the following references:
- Mu Gao and Jeffrey Skolnick, 2010. iAlign: a method for the structural comparison of protein-protein interfaces. Bioinformatics, 26(18):2259-65. PDF and Supplementary Material.
- Mu Gao and Jeffrey Skolnick, 2010. Structural space of protein-protein interfaces is degenerate, close to complete, and highly connected. PNAS 107(52):22517-22. PDF and Supplementary Material.
If you are looking for a tool for evaluating protein-protein docking models, check out IS-score.
This software is freely available to ALL users.
You may install and run iAlign locally.
This page is maintained by Mu Gao. Last updated 04/01/2014.