DNA-Binding Domain Hunter (DBD-Hunter) is a knowledge-based method for predicting DNA-binding proteins function from protein structure. The method combines structural comparison and evaluation of DNA-protein interaction energy, which is calculated use a statistical pair potential derived from crystal structures of DNA-protein complexes. Details of the method is described in the reference below.
To use the webservice of this program, please upload a protein structure file in the PDB format. The results will be sent back to your through e-mail address you provided.
- This service is freely available to academic users and not-for-profit institutions.
- Commercial users may request an evaluation copy or request to license the software by contacting Jeffrey Skolnick at firstname.lastname@example.org.
If you find the service useful, please cite the following publication:
M. Gao and J. Skolnick. 2008. DBD-Hunter: A knowledge-based method for the prediction of DNA-protein interactions. Nucleic Acids Research, 36(12): 3978-3992. PDF Supplementary
- DB179 (DNA-binding proteins)
- NB3797 (Non-DNA-binding proteins)
- APO-HOLO 104 (DNA-binding proteins in DNA-free and DNA-bound forms)
- SG1697 (Structural genomics targets)
Statistical Pair Potential
This page is maintained by Mu Gao.