Biomechanics and Motor Control Lab

Biomechanics and Motor Control Lab


Research Interests

The general research interests of the laboratory are Neural Control and Biomechanics of Movement. We study how neuromechanical systems with seemingly redundant number of degrees of freedom are managed by the nervous system to produce purposeful motor behaviors and how the neural control of motor behaviors is affected by injury (spinal cord or peripheral nerve injury, stroke, limb or vision loss).


Current Research Projects
  • Neural mechanisms of locomotion evoked by epidural stimulation of the spinal cord
    The overall goal of this project is to determine the contribution of motion-dependent afferent pathways, selected ascending and descending pathways in the spinocerebellar loop, and the central pattern generator (CPG) circuitry to the generation of the distinct kinematic and muscle synergies during normal walking and walking evoked by the epidural spinal cord stimulation (ES) in cats with intact and partially transected spinal cord. This goal will be accomplished in experimental and neuromechanical computational studies performed in close collaboration among 4 research groups: Georgia Institute of Technology (our lab); Karolinska Institute, Sweden; Drexel University and Pavlov Institute of Physiology, Russia. In this study, we use the neuromechanical computational model of spinal control of locomotion (Markin et al. 2016) to interpret the experimentally obtained kinematic and muscle synergies and activity patterns of spinal interneurons during the MLR-evoked and ES-evoked walking in the decerebrate cat.

model

  • Sensory Mechanisms of Functional Compensation After Peripheral Nerve Injury
    In this project we investigate (1) the effects of lost input from the primary spindle afferents in proximal muscles as a result of peripheral nerve injury and repair on interlimb, interjoint and intermuscle coordination during locomotion and (2) the mechanisms underlying functionally appropriate compensations after partial paralysis of a muscle group. This project involves close collaboration with Drs. Robert J. Gregor (Georgia Tech), Arthur W. English (Emory University), and T. Richard Nichols (Georgia Tech). Spinal circuitry and mechanical consequences of loss of muscle length feedback are simulated in collaboration with Dr. Donald H. Edwards (Georgia State University) using software AnimatLab developed in his group, Dr. Gennady Cymbalyuk (Georgia State University), and Dr. Ilya A. Rybak (Drexel University) using software NSM developed in his group.

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  • Mobility Skill Acquisition and Learning through Alternative and Multimodal Perception for Visually Impaired People
    In this project we study the role of different modes of sensory feedback information (visual, somatosensory, and tactile) in arm reaching tasks. To understand the process of sensorimotor integration during skill acquisition in these tasks, we perform measurements of brain activity and movement performance and also develop a model of sensorimotor integration. This project is conducted in collaboration with Drs. Zhigang Zhu, Tony Ro, Ying Li Tian, Kok-Meng Lee and Lewis Wheaton.

combo

  • Development of Tongue-Operated Exoskeleton for Stroke Rehabilitation4Brain
    In this project we collaborate with the groups of Drs. Maysam Ghovanloo (Georgia Tech), Andrew J. Butler (Georgia State University), and Minoru Shinohara (Georgia Tech) to develop novel therapeutic options for people with severe motor disabilities of the upper limbs.
  • Mechanics and Control of Precise Stepping5stepping
    In this collaborative project with Dr. Beloozerova (Barrow Neurological Institute) we ask how accurate stepping movements are organized and achieved and what are the biomechanical and neural mechanisms of accurate locomotor movements. We address these questions by assessing full-body mechanics, limb muscle activity, and activity of motor cortex during locomotor task with different demands on the accuracy of foot placement. Our subjects walk on a continuous flat surface, on horizontal ladders with rungs of different widths, and along narrow pathways.
  • Integration of the residual limb with a prosthesis via direct skin-bone-peripheral nerve interface.  This collaborative project with Drs. Mark Pitkin (Tufts University), Hangue Park (Taxes A&M University), Stephen P. DeWeerth (Lehigh University), and Martha Grover (Georgia Tech) focuses on the development of a sensing and powered limb prosthesis integrated with skin, bone and peripheral nerves and muscles.


Research Opportunities

Research opportunities related to the projects listed above are available for graduate and undergraduate students. Dr. Prilutsky is also a faculty member of the Georgia Tech’s Bioengineering Graduate Program and an adjunct faculty member of the Division of Physical Therapy at Emory University School of Medicine. Undergraduate students interested in research opportunities in the lab are encouraged to apply for the the President’s Undergraduate Research Awards.


Recently Organized Meetings/Workshops

Neuromechanical Modeling of Posture and Locomotion


Recent Publications
  • Books and book chapters
  1. Edwards, D.H., Prilutsky, B.I. Sensory feedback in the control of posture and locomotion. In: Neurobiology of Motor Control: Fundamental Concepts and New Directions (eds. Hooper SL, Büschges A). New York: Wiley, 263-304, 2017. PDF.
  2. Prilutsky BI, Edwards DH (editors). Neuromechanical Modeling of Posture and Locomotion. New York: Springer, 2016.
  3. Bondy B, Klishko AN, Edwards DH, Prilutsky BI, Cymbalyuk G. Control of cat walking and paw-shake by a multifunctional central pattern generator. In: Neuromechanical Modeling of Posture and Locomotion (eds. Prilutsky BI, Edwards DH, Jr). New York, NY: Springer, p. 333-359, 2016. PDF.
  4. Markin SN, Klishko AN, Shevtsova NA, Lemay MA, Prilutsky BI, Rybak IA. A neuromechanical model of spinal control of locomotion. In: Neuromechanical Modeling of Posture and Locomotion (eds. Prilutsky BI, Edwards DH, Jr). New York, NY: Springer, p. 21-65, 2016. PDF.
  5. Prilutsky BI, Klishko AN, Weber DJ, and Lemay MA. Computing motion dependent afferent activity during cat locomotion using a forward dynamics musculoskeletal model. In: Neuromechanical Modeling of Posture and Locomotion (eds. Prilutsky BI, Edwards DH, Jr). New York, NY: Springer, p. 273-307, 2016. PDF.
  6. Shevtsova NA, Hamade K, Chakrabarty S, Markin SN, Prilutsky BI, and Rybak IA. Modeling the organization of spinal neural circuits controlling two-joint muscles In: Neuromechanical Modeling of Posture and Locomotion (eds. Prilutsky BI, Edwards DH, Jr). New York, NY: Springer, p. 121-162, 2016. PDF.
  7. Zatsiorsky VM and Prilutsky BI. Biomechanics of Skeletal Muscles. Champaign, IL: Human Kinetics, 2012. (see also Japanese translation).
  8. Prilutsky BI and Klishko AN. Control of locomotion: Lessons from whole-body biomechanical analysis. In: Motor Control: Theories, Experiments, and Applications (eds. Danion F, Latash ML), pp. 159-178, 2010. PDF.
  • Peer-reviewed articles
  1. Lyle MA, Prilutsky BI, Gregor RJ, Abelew TA, Nichols TR. Self-reinnervated muscles lose autogenic length feedback, but intermuscular feedback can recover functional connectivity. J Neurophysiol. 116(3):1055-67, 2016. PubMed.
  2. Pantall A, Hodson-Tole EF, Gregor RJ, Prilutsky BI. Increased intensity and reduced frequency of EMG signals from feline self-reinnervated ankle extensors during walking do not normalize excessive lengthening. J Neurophysiol. 115(5):2406-20, 2016. PubMed.
  3. Mehta R, Maas H, Gregor RJ, Prilutsky BI. Unexpected fascicle length changes in denervated feline soleus muscle during stance phase of walking. Sci Rep. 5:17619, 2015. PubMed.
  4. Farrell BJ, Bulgakova MA, Sirota MG, Prilutsky BI, Beloozerova IN. Accurate stepping on a narrow path: mechanics, EMG, and motor cortex activity in the cat. J Neurophysiol. 114(5):2682-702, 2015. PubMed.
  5. Mehta R, Prilutsky BI. Task-dependent inhibition of slow-twitch soleus and excitation of fast-twitch gastrocnemius do not require high movement speed and velocity-dependent sensory feedback. Front Physiol. 5:410, 2014. PubMed.
  6. Klishko AN, Farrell BJ, Beloozerova IN, Latash ML, Prilutsky BI. Stabilization of cat paw trajectory during locomotion. J Neurophysiol. 112(6):1376-91, 2014. PubMed.
  7. Childers WL, Prilutsky BI, Gregor RJ. Motor adaptation to prosthetic cycling in people with trans-tibial amputation. J Biomech. 47(10):2306-13, 2014. PubMed.
  8. Farrell BJ, Bulgakova MA, Beloozerova IN, Sirota MG, Prilutsky BI. Body stability and muscle and motor cortex activity during walking with wide stance. J Neurophysiol. 112(3):504-24, 2014. PubMed.
  9. Farrell BJ, Prilutsky BI, Kistenberg RS, Dalton JF 4th, Pitkin M. An animal model to evaluate skin-implant-bone integration and gait with a prosthesis directly attached to the residual limb. Clin Biomech. 29(3):336-49, 2014. PubMed.
  10. Farrell BJ, Prilutsky BI, Ritter JM, Kelley S, Popat K, Pitkin M. Effects of pore size, implantation time, and nano-surface properties on rat skin ingrowth into percutaneous porous titanium implants. J Biomed Mater Res A. 102(5):1305-15, 2014. PubMed.
  11. Cronin NJ, Prilutsky BI, Lichtwark GA, Maas H. Does ankle joint power reflect type of muscle action of soleus and gastrocnemius during walking in cats and humans? J Biomech. 46(7):1383-6, 2013. PubMed.
  12. Hodson-Tole EF, Pantall A, Maas H, Farrell BJ, Gregor BJ, Prilutsky BI. (2012) Task dependent activity of motor unit populations in feline ankle extensor muscles. J Exp Biol. 215(Pt 21):3711-22, 2012. PubMed.
  13. Pantall A, Gregor RJ, Prilutsky BI. (2012) Stance and swing phase detection during level and slope walking in the cat: effects of slope, injury, subject and kinematic detection method. J Biomech. 45(8):1529-1533. PubMed.
  14. Markin SN, Lemay MA, Prilutsky BI, Rybak IA. (2012) Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study. J Neurophysiol. 107(8):2057-2071. PubMed.